Basophil sensitivity through CD63 or CD203c is a functional measure for specific immunotherapy
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چکیده
منابع مشابه
Basophil sensitivity through CD63 or CD203c is a functional measure for specific immunotherapy
BACKGROUND Subcutaneous Immunotherapy (SCIT) modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitivity, measured through the basophil activation test, would decrease during SCIT up dosing. Expression of CD203c was compared to CD63 as marker for basophil activation, using a Bl...
متن کاملComparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy.
BACKGROUND To confirm allergy to beta-lactam (BL), a basophil activation test in flow cytometry based on CD63 up-regulation was described. CD203c is a more recent basophil activation marker and up to day there is no consensus about which marker is the more sensitive one. CD203c has not yet been evaluated in the diagnosis of BL allergy. OBJECTIVE The aim of the study was to compare the reliabi...
متن کاملHypersensitivity to fluoroquinolones
Although fluoroquinolones (FQs) are generally well-tolerated antibiotics, increasing numbers of hypersensitivity reactions have been reported. These can be evaluated in vitro by basophil activation tests (BATs); however, sensitivity is not optimal. Many factors could influence sensitivity such as basophil activation markers. The objective of this study was to evaluate the influence of 2 differe...
متن کاملActivation Markers CD63 and CD203c Are Upregulated in Chronic Urticaria
522 Ann Dermatol Received November 15, 2012, Revised January 25, 2013, Accepted for publication January 28, 2013 Corresponding author: Hans Jürgen Hoffmann, Allergy Center for West Denmark, Department of Pulmonary Medicine, Health: Aarhus University, Building 2b, Nørrebrogade 44, DK 8000 Aarhus C, Denmark. Tel: 45-78462107, Fax: 45-78462110, E-mail: hans.jurgen.hoffmann @ki.au.dk This is an Ope...
متن کاملBasophil Markers for Identification and Activation in the Indirect Basophil Activation Test by Flow Cytometry for Diagnosis of Autoimmune Urticaria
BACKGROUND The indirect basophil activation test using flow cytometry is a promising tool for autoimmune urticaria diagnosis. We aimed to identify better donor basophils (from atopic vs. non-atopic donors and interleukin-3 primed vs. unprimed basophils) and improve basophil identification and activation markers (eotaxin CC chemokine receptor-3 [CCR3] vs. CD123 and CD63 vs. CD203c). METHODS Do...
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ژورنال
عنوان ژورنال: Clinical and Molecular Allergy
سال: 2010
ISSN: 1476-7961
DOI: 10.1186/1476-7961-8-2